* {
  box-sizing: border-box;
}

html {
  scroll-behavior: smooth;
}

:root {
  --navy: #1a3a5c;
  --navy-2: #0f2942;
  --navy-3: #0a2035;
  --blue: #2b6f9f;
  --blue-soft: #eaf3f8;
  --cyan: #68b9d6;
  --ink: #172331;
  --text: #435469;
  --muted: #728096;
  --line: #dce6ee;
  --paper: #ffffff;
  --off-white: #f6f9fb;
  --radius: 22px;
  --shadow: 0 28px 70px rgba(25, 58, 92, 0.10);
}

body {
  margin: 0;
  color: var(--ink);
  background: var(--paper);
  font-family: -apple-system, BlinkMacSystemFont, "Segoe UI", Roboto, Helvetica, Arial, sans-serif;
  line-height: 1.6;
  -webkit-font-smoothing: antialiased;
}

a {
  color: inherit;
}

.container {
  width: min(1180px, calc(100% - 48px));
  margin: 0 auto;
}

.site-header {
  position: sticky;
  top: 0;
  z-index: 50;
  background: rgba(255, 255, 255, 0.92);
  backdrop-filter: blur(18px);
  border-bottom: 1px solid rgba(220, 230, 238, 0.85);
}

.nav {
  min-height: 76px;
  display: flex;
  align-items: center;
  justify-content: space-between;
  gap: 28px;
}

.brand {
  display: inline-flex;
  align-items: center;
  gap: 11px;
  text-decoration: none;
}

.brand-mark {
  width: 39px;
  height: 39px;
  display: grid;
  place-items: center;
  border-radius: 12px;
  background: var(--navy);
}

.brand-mark svg {
  width: 31px;
  height: 31px;
  fill: none;
  stroke: #fff;
  stroke-width: 2.15;
  stroke-linecap: round;
  stroke-linejoin: round;
}

.brand strong,
.brand small {
  display: block;
}

.brand strong {
  color: var(--navy);
  font-size: 1.02rem;
  letter-spacing: 0.06em;
}

.brand small {
  color: var(--muted);
  margin-top: -2px;
  font-size: 0.69rem;
  letter-spacing: 0.05em;
  text-transform: uppercase;
}

.nav-links {
  display: flex;
  align-items: center;
  gap: 29px;
}

.nav-links a {
  color: #526174;
  font-size: 0.91rem;
  font-weight: 600;
  text-decoration: none;
}

.nav-links a:hover {
  color: var(--navy);
}

.nav-links .nav-login {
  color: var(--navy);
  border: 1px solid #bfd0dd;
  border-radius: 999px;
  padding: 9px 15px;
}

.hero {
  position: relative;
  overflow: hidden;
  background:
    radial-gradient(circle at 78% 14%, rgba(104, 185, 214, 0.12), transparent 29%),
    linear-gradient(180deg, #fbfdff 0%, #ffffff 100%);
}

.hero-grid {
  min-height: 720px;
  padding: 88px 0 94px;
  display: grid;
  grid-template-columns: 1.04fr 0.96fr;
  align-items: center;
  gap: 78px;
}

.eyebrow {
  margin-bottom: 20px;
  color: var(--blue);
  font-size: 0.76rem;
  font-weight: 800;
  letter-spacing: 0.16em;
  text-transform: uppercase;
}

.eyebrow.light {
  color: #8ed1e8;
}

.hero h1 {
  margin: 0;
  max-width: 760px;
  color: var(--navy-2);
  font-size: clamp(3.3rem, 6vw, 5.8rem);
  line-height: 0.99;
  letter-spacing: -0.058em;
  font-weight: 760;
}

.hero h1 span {
  color: var(--blue);
}

.hero-lead {
  max-width: 670px;
  margin: 31px 0 0;
  color: var(--text);
  font-size: 1.18rem;
  line-height: 1.72;
}

.hero-actions {
  display: flex;
  gap: 12px;
  flex-wrap: wrap;
  margin-top: 35px;
}

.button {
  display: inline-flex;
  align-items: center;
  justify-content: center;
  min-height: 48px;
  padding: 0 21px;
  border-radius: 12px;
  font-size: 0.92rem;
  font-weight: 750;
  text-decoration: none;
  transition: transform 0.2s ease, box-shadow 0.2s ease, background 0.2s ease;
}

.button:hover {
  transform: translateY(-1px);
}

.button-primary {
  color: #fff;
  background: var(--navy);
  box-shadow: 0 12px 26px rgba(26, 58, 92, 0.18);
}

.button-primary:hover {
  background: #244d73;
}

.button-secondary {
  color: var(--navy);
  background: #fff;
  border: 1px solid #cddae4;
}

.hero-note {
  margin: 20px 0 0;
  color: #7a8898;
  font-size: 0.82rem;
}

.hero-visual {
  position: relative;
  min-height: 520px;
  display: grid;
  place-items: center;
}

.hero-orb {
  position: absolute;
  border-radius: 50%;
  pointer-events: none;
}

.hero-orb-one {
  width: 340px;
  height: 340px;
  right: -130px;
  top: 80px;
  border: 1px solid rgba(43, 111, 159, 0.08);
}

.hero-orb-two {
  width: 520px;
  height: 520px;
  right: -210px;
  top: -5px;
  border: 1px solid rgba(43, 111, 159, 0.05);
}

.signal-card {
  width: min(100%, 470px);
  position: relative;
  border: 1px solid #dce8f0;
  border-radius: 28px;
  background: rgba(255, 255, 255, 0.96);
  box-shadow: var(--shadow);
}

.signal-card-main {
  padding: 28px;
}

.signal-card-top {
  display: flex;
  align-items: center;
  gap: 9px;
  color: #6c7a8d;
  font-size: 0.78rem;
  font-weight: 700;
  letter-spacing: 0.04em;
  text-transform: uppercase;
}

.pulse-dot {
  width: 8px;
  height: 8px;
  border-radius: 50%;
  background: var(--cyan);
  box-shadow: 0 0 0 6px rgba(104, 185, 214, 0.13);
}

.signal-lines {
  display: grid;
  gap: 9px;
  margin: 25px 0 28px;
}

.signal-lines span {
  display: block;
  width: var(--w);
  height: 7px;
  border-radius: 999px;
  background: linear-gradient(90deg, #dceaf2, #eef5f9);
}

.engine {
  min-height: 230px;
  display: flex;
  flex-direction: column;
  align-items: center;
  justify-content: center;
  border-radius: 22px;
  background:
    radial-gradient(circle at center, rgba(104, 185, 214, 0.13), transparent 46%),
    #f7fafc;
  border: 1px solid #e2ecf2;
}

.engine-label {
  color: var(--navy);
  font-size: 1.2rem;
  font-weight: 850;
  letter-spacing: 0.11em;
}

.engine-ring {
  position: relative;
  width: 86px;
  height: 86px;
  margin: 12px 0 10px;
  border-radius: 50%;
  border: 1px solid #b8d6e6;
}

.engine-ring::before,
.engine-ring::after {
  content: "";
  position: absolute;
  border-radius: 50%;
  border: 1px solid #d1e4ee;
}

.engine-ring::before {
  inset: 10px;
}

.engine-ring::after {
  inset: 23px;
  background: var(--navy);
  box-shadow: 0 0 0 8px rgba(26, 58, 92, 0.06);
}

.engine-ring span {
  position: absolute;
  width: 7px;
  height: 7px;
  background: var(--cyan);
  border-radius: 50%;
}

.engine-ring span:nth-child(1) {
  left: 7px;
  top: 18px;
}

.engine-ring span:nth-child(2) {
  right: 2px;
  top: 41px;
}

.engine-ring span:nth-child(3) {
  left: 38px;
  bottom: -4px;
}

.engine-caption {
  color: #66788a;
  font-size: 0.8rem;
}

.pathway-mini {
  display: grid;
  grid-template-columns: 1fr auto 1fr auto 1fr;
  align-items: center;
  gap: 12px;
  margin-top: 25px;
}

.pathway-mini div {
  text-align: center;
}

.pathway-mini b,
.pathway-mini span {
  display: block;
}

.pathway-mini b {
  color: #91a1b3;
  font-size: 0.68rem;
  margin-bottom: 2px;
}

.pathway-mini span {
  color: var(--navy);
  font-size: 0.78rem;
  font-weight: 750;
}

.pathway-mini i {
  width: 22px;
  height: 1px;
  background: #cbd9e2;
}

.floating-label {
  position: absolute;
  padding: 10px 13px;
  border: 1px solid #d8e5ed;
  border-radius: 10px;
  background: rgba(255,255,255,0.94);
  color: #617386;
  box-shadow: 0 12px 30px rgba(26, 58, 92, 0.08);
  font-size: 0.76rem;
  font-weight: 700;
}

.floating-label-a {
  left: -8px;
  top: 80px;
}

.floating-label-b {
  right: -18px;
  bottom: 63px;
}

.section {
  padding: 105px 0;
}

.split {
  display: grid;
  grid-template-columns: 1fr 0.85fr;
  gap: 100px;
}

h2 {
  margin: 0;
  color: var(--navy-2);
  font-size: clamp(2.2rem, 4vw, 3.7rem);
  line-height: 1.1;
  letter-spacing: -0.045em;
}

.section-copy {
  padding-top: 35px;
}

.section-copy p,
.clinical-grid p,
.vision-grid p {
  color: var(--text);
  font-size: 1.04rem;
  line-height: 1.78;
}

.pathway {
  display: grid;
  grid-template-columns: 1fr auto 1fr auto 1fr auto 1fr;
  align-items: start;
  gap: 18px;
  margin-top: 68px;
  padding-top: 38px;
  border-top: 1px solid var(--line);
}

.pathway-step span {
  display: block;
  color: #9aa9b7;
  font-size: 0.72rem;
  font-weight: 800;
  margin-bottom: 8px;
}

.pathway-step strong {
  display: block;
  color: var(--navy);
  font-size: 1.08rem;
}

.pathway-step p {
  margin: 7px 0 0;
  color: #6f7d8c;
  font-size: 0.88rem;
  line-height: 1.55;
}

.pathway-arrow {
  padding-top: 27px;
  color: #aab9c5;
}

.real-world-section {
  background: var(--off-white);
  border-top: 1px solid #edf2f5;
  border-bottom: 1px solid #edf2f5;
}

.section-heading {
  max-width: 760px;
}

.section-heading.centered {
  margin: 0 auto;
  text-align: center;
}

.section-heading p {
  margin: 24px auto 0;
  max-width: 760px;
  color: var(--text);
  font-size: 1.03rem;
  line-height: 1.78;
}

.metrics {
  display: grid;
  grid-template-columns: repeat(4, 1fr);
  gap: 16px;
  margin-top: 53px;
}

.metric {
  min-height: 150px;
  padding: 28px;
  border: 1px solid #dce6ed;
  border-radius: 18px;
  background: #fff;
}

.metric strong,
.metric span {
  display: block;
}

.metric strong {
  color: var(--navy);
  font-size: 2.2rem;
  letter-spacing: -0.045em;
}

.metric span {
  margin-top: 7px;
  color: #6d7b8b;
  font-size: 0.86rem;
}

.data-separation-note {
  max-width: 760px;
  margin: 22px auto 0;
  color: #8793a1;
  text-align: center;
  font-size: 0.77rem;
  line-height: 1.6;
}

.science-section {
  color: #fff;
  background:
    radial-gradient(circle at 74% 30%, rgba(104,185,214,0.14), transparent 28%),
    linear-gradient(135deg, var(--navy-3), var(--navy));
}

.science-grid {
  display: grid;
  grid-template-columns: 0.78fr 1.22fr;
  gap: 84px;
  align-items: center;
}

.science-copy h2,
.vision-section h2 {
  color: #fff;
}

.science-copy p {
  color: #c8d6e1;
  font-size: 1rem;
  line-height: 1.78;
}

.study-badge {
  width: fit-content;
  display: flex;
  align-items: center;
  gap: 15px;
  margin-top: 31px;
  padding: 10px 15px;
  border: 1px solid rgba(255,255,255,0.15);
  border-radius: 999px;
  background: rgba(255,255,255,0.06);
}

.study-badge span {
  color: #afc4d3;
  font-size: 0.75rem;
}

.study-badge strong {
  font-size: 0.89rem;
}

.science-panel {
  padding: 33px;
  border: 1px solid rgba(255,255,255,0.13);
  border-radius: 24px;
  background: rgba(255,255,255,0.07);
  box-shadow: 0 30px 80px rgba(0,0,0,0.17);
}

.science-metrics {
  display: grid;
  grid-template-columns: repeat(2, 1fr);
  gap: 12px;
}

.science-metric {
  min-height: 133px;
  padding: 23px;
  border: 1px solid rgba(255,255,255,0.12);
  border-radius: 17px;
  background: rgba(255,255,255,0.055);
}

.science-metric span,
.science-metric strong {
  display: block;
}

.science-metric span {
  color: #a9c0d0;
  font-size: 0.77rem;
  text-transform: uppercase;
  letter-spacing: 0.08em;
}

.science-metric strong {
  margin-top: 6px;
  font-size: 2rem;
  letter-spacing: -0.035em;
}

.polygraphy-context {
  margin: 17px 2px 0;
  padding-left: 19px;
  color: #b8cad6;
  font-size: 0.76rem;
  line-height: 1.55;
}

.polygraphy-context li + li {
  margin-top: 4px;
}

.kappa-row {
  display: grid;
  grid-template-columns: 0.7fr 1.3fr;
  gap: 12px;
  margin-top: 12px;
}

.kappa-row > div {
  min-height: 106px;
  padding: 20px 22px;
  border: 1px solid rgba(255,255,255,0.12);
  border-radius: 17px;
  background: rgba(255,255,255,0.055);
}

.kappa-row span,
.kappa-row strong {
  display: block;
}

.kappa-row span {
  color: #a9c0d0;
  font-size: 0.74rem;
}

.kappa-row strong {
  margin-top: 6px;
  font-size: 1.42rem;
}

.confirmed-cases-note p {
  margin: 8px 0 0;
  color: #dce8ef;
  font-size: 0.83rem;
  line-height: 1.45;
}

.confirmed-cases-note p strong {
  display: inline;
  font-size: inherit;
}

.science-footnote {
  margin: 18px 2px 0;
  color: #91aabe;
  font-size: 0.72rem;
  line-height: 1.55;
}

.clinical-grid {
  display: grid;
  grid-template-columns: 0.9fr 1.1fr;
  align-items: center;
  gap: 90px;
}

.clinical-visual {
  min-height: 410px;
  display: grid;
  place-items: center;
  border-radius: 26px;
  background:
    linear-gradient(rgba(255,255,255,0.78), rgba(255,255,255,0.78)),
    radial-gradient(circle at 50% 42%, #b9dbe9, #eef5f8 55%, #f7fafc);
  border: 1px solid #e0e9ef;
}

.doctor-card {
  width: min(85%, 370px);
  display: flex;
  align-items: center;
  gap: 18px;
  padding: 22px;
  border-radius: 18px;
  background: #fff;
  border: 1px solid #dae6ed;
  box-shadow: 0 20px 50px rgba(26,58,92,0.10);
}

.doctor-icon {
  width: 66px;
  height: 66px;
  display: grid;
  place-items: center;
  flex: 0 0 auto;
  border-radius: 17px;
  background: var(--blue-soft);
}

.doctor-icon svg {
  width: 40px;
  height: 40px;
  fill: none;
  stroke: var(--navy);
  stroke-width: 2;
  stroke-linecap: round;
}

.doctor-card span,
.doctor-card strong {
  display: block;
}

.doctor-card span {
  color: #8a98a7;
  font-size: 0.72rem;
  text-transform: uppercase;
  letter-spacing: 0.08em;
}

.doctor-card strong {
  color: var(--navy);
  margin-top: 4px;
  font-size: 1rem;
}

.clean-list {
  display: grid;
  gap: 11px;
  padding: 0;
  margin: 30px 0 0;
  list-style: none;
}

.clean-list li {
  position: relative;
  padding-left: 28px;
  color: #42546a;
  font-size: 0.92rem;
}

.clean-list li::before {
  content: "✓";
  position: absolute;
  left: 0;
  color: var(--blue);
  font-weight: 900;
}

.deployment-section {
  background: var(--off-white);
}

.deployment-grid {
  display: grid;
  grid-template-columns: repeat(4, 1fr);
  gap: 14px;
  margin-top: 50px;
}

.deployment-card {
  min-height: 250px;
  padding: 26px;
  border: 1px solid #dce6ed;
  border-radius: 18px;
  background: #fff;
}

.card-number {
  color: #a3b1bd;
  font-size: 0.72rem;
  font-weight: 800;
}

.deployment-card h3 {
  margin: 55px 0 11px;
  color: var(--navy);
  font-size: 1.09rem;
}

.deployment-card p {
  margin: 0;
  color: #708090;
  font-size: 0.86rem;
  line-height: 1.63;
}

.integration-strip {
  display: flex;
  align-items: center;
  justify-content: center;
  gap: 20px;
  margin-top: 29px;
  padding: 19px 22px;
  border: 1px solid #dce6ed;
  border-radius: 14px;
  color: #5d6f81;
  background: #fff;
  font-size: 0.78rem;
  font-weight: 700;
}

.integration-strip i {
  width: 4px;
  height: 4px;
  border-radius: 50%;
  background: #aab8c4;
}

.vision-section {
  color: #fff;
  background: #0b263e;
}

.vision-grid {
  display: grid;
  grid-template-columns: 1fr 0.88fr;
  gap: 100px;
}

.vision-grid p {
  margin-top: 0;
  color: #bfd0dc;
}

.vision-statement {
  margin-top: 31px !important;
  padding-left: 21px;
  border-left: 2px solid var(--cyan);
}

.vision-statement strong {
  color: #fff;
}

.maastricht-section {
  padding: 72px 0;
}

.maastricht-card {
  min-height: 310px;
  display: flex;
  align-items: center;
  justify-content: space-between;
  gap: 60px;
  padding: 52px;
  border: 1px solid #dbe7ef;
  border-radius: 26px;
  background:
    radial-gradient(circle at 85% 16%, rgba(104,185,214,0.16), transparent 30%),
    #f8fbfd;
}

.event-label {
  display: inline-block;
  margin-bottom: 16px;
  color: var(--blue);
  font-size: 0.74rem;
  font-weight: 850;
  letter-spacing: 0.12em;
  text-transform: uppercase;
}

.maastricht-card h2 {
  font-size: clamp(2.4rem, 4vw, 3.3rem);
}

.maastricht-card p {
  max-width: 650px;
  margin: 15px 0 0;
  color: #607184;
}

.maastricht-actions {
  display: flex;
  flex-direction: column;
  gap: 10px;
  min-width: 190px;
}

.site-footer {
  color: #d5e1e9;
  background: #091c2d;
  padding: 54px 0 28px;
}

.footer-grid {
  display: flex;
  align-items: flex-start;
  justify-content: space-between;
  gap: 40px;
}

.footer-grid strong {
  color: #fff;
  letter-spacing: 0.08em;
}

.footer-grid p {
  margin: 7px 0 0;
  color: #8fa6b7;
  font-size: 0.84rem;
}

.footer-links {
  display: flex;
  flex-wrap: wrap;
  gap: 22px;
}

.footer-links a {
  color: #afc0cd;
  font-size: 0.82rem;
  text-decoration: none;
}

.footer-bottom {
  display: flex;
  justify-content: space-between;
  gap: 20px;
  margin-top: 44px;
  padding-top: 20px;
  border-top: 1px solid rgba(255,255,255,0.09);
  color: #718a9d;
  font-size: 0.71rem;
}

@media (max-width: 1000px) {
  .hero-grid,
  .science-grid,
  .clinical-grid,
  .vision-grid {
    grid-template-columns: 1fr;
  }

  .hero-grid {
    gap: 25px;
  }

  .hero-visual {
    min-height: 480px;
  }

  .science-grid,
  .clinical-grid,
  .vision-grid {
    gap: 52px;
  }

  .metrics,
  .deployment-grid {
    grid-template-columns: repeat(2, 1fr);
  }

  .split {
    grid-template-columns: 1fr;
    gap: 18px;
  }

  .section-copy {
    padding-top: 0;
  }

  .maastricht-card {
    align-items: flex-start;
    flex-direction: column;
  }

  .maastricht-actions {
    flex-direction: row;
    width: 100%;
  }
}

@media (max-width: 760px) {
  .container {
    width: min(100% - 30px, 1180px);
  }

  .site-header {
    position: static;
  }

  .nav {
    min-height: 70px;
  }

  .nav-links a:not(.nav-login) {
    display: none;
  }

  .nav-links {
    gap: 0;
  }

  .nav-links .nav-login {
    padding: 8px 12px;
    font-size: 0.8rem;
  }

  .hero-grid {
    min-height: auto;
    padding: 67px 0 70px;
  }

  .hero h1 {
    font-size: clamp(3rem, 14vw, 4.5rem);
  }

  .hero-lead {
    font-size: 1.02rem;
  }

  .hero-visual {
    min-height: 430px;
  }

  .floating-label-a {
    left: 0;
  }

  .floating-label-b {
    right: 0;
  }

  .section {
    padding: 76px 0;
  }

  h2 {
    font-size: clamp(2.1rem, 10vw, 3rem);
  }

  .pathway {
    grid-template-columns: 1fr;
    gap: 25px;
  }

  .pathway-arrow {
    display: none;
  }

  .metrics,
  .deployment-grid,
  .science-metrics,
  .kappa-row {
    grid-template-columns: 1fr;
  }

  .metric {
    min-height: 128px;
  }

  .science-panel {
    padding: 18px;
  }

  .clinical-visual {
    min-height: 330px;
  }

  .integration-strip {
    align-items: flex-start;
    flex-direction: column;
    gap: 8px;
  }

  .integration-strip i {
    display: none;
  }

  .maastricht-card {
    padding: 31px 25px;
  }

  .maastricht-actions {
    flex-direction: column;
  }

  .footer-grid,
  .footer-bottom {
    flex-direction: column;
  }
}

@media (prefers-reduced-motion: reduce) {
  html {
    scroll-behavior: auto;
  }

  .button {
    transition: none;
  }
}

/* TEMP — embargo Maastricht 2026. Supprimer ce bloc après le congrès. */
a[href="#science"],
#science,
.maastricht-section {
  display: none !important;
}